Profiling Metabolite Changes Within The Neuronal...

Profiling metabolite changes in the neuronal differentiation of human striatal neural stem cells using 1H-Magnetic Resonance Spectroscopy Yuen-Li Chung1, Gehan El Akabawy2,3, Po-Wah So4, Bhavana S. Solanky2,*, Martin O. Leach1, and Michel Modo2,5 1The Institute of Cancer Research and Royal Marsden Hospital, Cancer Research UK and EPSRC Cancer Imaging Centre, Sutton, Surrey, SM2 5PT, UK 2Kings College London, Institute of Psychiatry, Department of Neuroscience, London, SE5 9NU, UK 3University of Menoufia, Department of Anatomy and Embryology, Faculty of Medicine, Menoufia, Egypt 4Kings College London, Institute of Psychiatry, Department of Neuroimaging, London, SE5 9NU, UK 5University of Pittsburgh, Department of Radiology, McGowan Institute for Regenerative Medicine, Pittsburgh PA5203, USA Abstract Objective—Neural stem cells (NSCs) are playing an increasing clinical role for stroke. However at present, it is not yet possible to non-invasively monitor their differentiation once implanted into the brain. Methods—We here describe the use of high-resolution 1H-magnetic resonance spectroscopy (MRS) to define a metabolite profile of undifferentiated human striatal NSCs from the STROC05 cell line and their differentiation after 3 weeks of treatment with purmorphamine. Results—The undifferentiated conditions were characterized by ∠¼95% of cells expressing nestin and ∠¼77% being Ki67+, indicating that these were still proliferating. Phosphophocholine +glycerophosphocholine (PC+GPC)

Essay about Another Chance Of Life - 774 Words

Another Chance of Life Can there be another you? The answer is no, but by human cloning you can reproduce an offspring that grows into an exact genetically double of you. All of us want to prolong the lives of our loved ones and have a healthy newborn baby. Many infertility couples wanted to have a baby that is genetically theirs, not from adopting a child from a different family background. In the cloning technology, eggs or sperms would not be needed to be conceived by a person because any cell would do. One parent contributes DNA, making the child almost an identical twin. He or she would differ from the parents much more than identical twins differ from each other. In many parts of the world, human cloning is banned. For example,†¦show more content†¦The child from cloning is not a copy, but a unique individual. 1.5 million identical twins are far from being identical. They have different brain structures, IQs, fingerprints, and personalities. The concern is the way people think about cloning. quot;Its not that anyone thinks there is a commandment, Thou shalt not clone, but there are limits to what humans out to be thinking about doing,quot; said Margaret O Brien Steinfels of Catholic commonwealth magazine. People fear that cloning will become a tool to copy their greatest players. Now, Germany had developed laws governing the cloning procedures so that cloning is used solely for the benefits of the country. In the United States, the government cuts off funding for projects that seem offensive. Cloning is financed largely by the flourishing in-vitro fertilization business. Human cloning is the following step that started with in vitro fertilization to help couples who had troubles of getting pregnant. The embryo cloning increases the chances of a successful pregnancy for infertility couples. Fifteen percent of a dults suffer from infertility that cannot be cured by current medicine. Millions cannot have children because that cannot produce more than one embryo. The in vitro (out of the body) fertilization aimed at developing fertilized eggs in test tubes can be implanted into the wombs of women havingShow MoreRelatedEssay on Run Lola Run Analysis988 Words   |  4 Pagesfrom the beginning. The repetition of the run in which we see the same scene three times is an example of how Lolas journey is similar to the likes of a video game. This works to emphasise the fact that her life can just be rewinded and restarted just like video games. Even though, in real life we cannot travel back it time, the repetition of the run sequence shows mistakes are fixed by going back to the root of the problem. 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Why and How Have Liberals Supported the Fragmentation Free Essays

Why and how have liberals supported the fragmentation of political power? (15) Why Liberals are concerned about power, most basically, because power constitutes a threat to liberty. Their concern about concentrations of power is rooted in their emphasis upon individualism and its implication that human beings are rationally self- interested creatures. Egoism determines that those who have the ability to influence behaviour of others are inevitably inclined to use that ability for their own benefit and therefore at the expense of others. We will write a custom essay sample on Why and How Have Liberals Supported the Fragmentation or any similar topic only for you Order Now The greater the concentration of power, the greater will be the scope of rulers to pursue self-interest and, thus, the greater corruption. Lord Acton stated â€Å"Power tends to corrupt, and absolute power corrupts absolutely. Great men are almost always bad men. † behind Acton’s famous quote about power and corruption, he points out the liberal belief that, since human beings are individuals and therefore egoistical, they are bound to use power – the ability to influence the behaviour of others to benefit themselves and they will use, or abuse, others in the furtherance of that goal. In essence, the greater the power the greater the scope for using and abusing others in the pursuit of self-seeking ends. Such thinking has shaped liberalism in a number of ways. In particular it has encouraged them to endorse the principle of limited government brought through constitutionalism and democracy. Liberals thus support, for example, codified constitutions, bills of rights, the separation of powers, federalism or devolution, as well as regular, free and fair elections, party competition and universal suffrage. Constitutionalism delivers limited government either by legally ring-fencing government (e. . , codified constitutions and bills of rights or fragmenting government power so creating a network of checks and balances (e. g. , the separation of powers, bicameralism and federalism). Democracy delivers limited government because it bases government on a system of popular consent and accountably that also enables the public (through competitive elections) to rid themselv es of unpopular or corrupt governments. The fragmentation of power brings many significant benefits. It creates a network of checks and a balance, ensuring that power is a check on power. Different bodies and institutions will eventually act as a check on each other. Fragmented government therefore creates internal constraints that prevent government from becoming a tyranny against the individual. Furthermore, it ensures that those who exercise power have only a limited ability to influence other citizens, thus preventing absolute power. How Traditionally, liberals have always supported fragmented government, checks and balances. Power within liberal democracies is separated between the legislature, executive and judiciary which act as both independent and inter-dependent bodies. The separation of powers emphasises it cuts on power into smaller pieces – thus preventing concentrations of power from developing – and that it creates internal tensions amongst institutions and power-holders which further diminishes the capacity of each to abuse or tyrannise the general public. Liberals support constitutionalism and consent because they fear that government may become a tyranny against the individual, based on the assumption that power is inherently corrupting and concentrations of power will lead to absolute corruption. This assumption is rooted in the liberal view of human nature: as individualism implies self- interest, those with power over others are apt to abuse it for their benefit and at the expense of others. Constitutionalism is the theory or practice of restricting government power through the establishment of a framework of constitutional regulations, usually involving the fragmentation of power to create a network of checks and balances. Liberal constitutionalism is expressed through support for various external and internal devices, such as codified constitutions, bills of rights, the separation of powers, federalism or devolution, and so on. Liberal support for consent is evident in support for electoral democracy in general and, more specifically, sympathy for referendums and proportional representation. Consent is the principle that the right to govern derives from the willing agreement of the governed, who thus view the actions of government as rightful or legitimate. Consent is often in practice associated with the act of voting and therefore institutionalised through a system of electoral democracy. Liberals emphasise the importance of constitutionalism and onsent because both are mechanisms for protecting or enlarging the sphere of individual liberty by restricting the capacity of government to encroach upon the individual. This commitment to limiting government reflects the underlying liberal fear that power is inherently corrupting, a consequence of egoism, meaning that government is always liable to become a tyranny against the individual. Constitutionalism achieved this aim through formal, institutional and oft en legal restrictions upon government officials and bodies. Consent achieves it by ensuring that politicians are publicly accountable and, ultimately, removable. ? Federalism, based on the principle of shared sovereignty, devolution, parliamentary government, cabinet government and so on. ? Power is devolved from the centre to regions and at local levels. In the UK: regional assemblies- welsh assembly; Scottish parliament ? Human rights act: giving people rights in law which means that they have a check to defend themselves from being discriminated against by those in authority How to cite Why and How Have Liberals Supported the Fragmentation, Essay examples

Words and Music free essay sample

â€Å"And now, Akshita and Aisha will be performing â€Å"Te Amo† by Rihanna!† Wearing masks of timidity and terror, we inched our way towards the center of the stage, reluctant to meet the eyes of the hypercritical audience. The speakers overhead began to blast the Latino beats of Rihanna’s popular love song, and the audience began to scream. We were exhilarated, pumped and ready to put on a show that would be unforgettable. I looked Aisha in the eyes, took a deep breath, and began to sing. The first time I had ever sung in front of an audience was at church when I was in sixth grade. My teachers would say, â€Å"Good hymnody has an enduring effect.† I altered the quote so it read, â€Å"Good singing has an enduring effect.† With that in mind, I aimed to master the art of singing. Singing has been my passion since then. I sing whenever and wherever I can. We will write a custom essay sample on Words and Music or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Singing isn’t only a passion, it’s my motivation. Those high notes I hit really push me to hit higher goals in life. It gives me the energy and power to further myself. â€Å"The Catholic Daughters of the Americas Contest: For all students from all grade levels† read the flyer on my classroom door. For more information, I asked my teacher what the contest was all about. I learned that it was a contest in which students were to submit an essay, a poem, an artwork, or a song on the power of Jesus’ love. There are three winners from the each district, and the first place winner of each district would enter a statewide contest. I was announced first place for my school, first place in the district, and eventually second place in the state of New Jersey in the music department. Being one of the few Indian students who attended this predominantly Caucasian school, I was exhilarated when the news got to me. Singing isn’t about religion; it’s about the power of words and your ability to project them in a melodious fashion. It’s about touching the souls of the people, and enlivening them. Music has a powerful effect on the emotions of people. It helps me concentrate when I really need it. Singing isn’t only my passion, it’s my motivation. Furthermore, it’s my way to connect with people.

Two Heads Are Better Than One Essays

Two Heads Are Better Than One Essays Two Heads Are Better Than One Essay Two Heads Are Better Than One Essay Two Heads Are Better Than One Two heads are better than one. Is working in a group better than working independently? I think so because you can get more ideas, do the work in a quicker time period and accomplish bigger goals. Firstly, if you work in a group there are more people with you which means there is a variety of thinkers. A variety of thinkers means a mixture of ideas and more success. For example, say you and your staff members have created a product and you want to advertise it in many ways. If you were just working on it alone, you probably wouldn’t get as many results as well as the same quality of work as you would in a group. Secondly, when you do group work instead of individual work, you tend to do the work much faster because the work is divided. The more and more people there are, the lesser time it takes to finish the same work. Let’s take a simple example, a project on aeroplanes. You have to answer about 6 questions on aeroplanes and make a poster board. If you are working in a group, you can divide all the work to each member of the group (answering questions, designing the board, editing, etc. and the process will go much quicker than you having to do all of it yourself. So group work is done much quicker than individual work. Lastly, when you work in a group you can accomplish bigger goals because there are more people. For example, say you have a goal to help the hungry people in the community. If you try to accomplish this goal by yourself, it would be very difficult to do. But when you make an organization, everybody can help and you will meet the needs of your goal. To sum up, it is better to work in a group than to work individually. Thus, two heads are better than one.

Practice in Using the Present Perfect in English

Practice in Using the Present Perfect in English Once you understand how to form the past tense of regular verbs, you shouldnt find it difficult to use verbs in the present perfect. All youll need to add is an auxiliary verb (also known as a helping verb)has or have. Using Has and Have With Past Participles Coupled with the auxiliary verb has  or have, a past participle can serve as the main verb in a sentence. Compare these two sentences: Carla worked here for five years.Carla has worked here for five years. The first sentence is in the past tense: Carla once worked here but no longer does. The second sentence carries a different meaning: Carla still works here. We use has or have with a past participle to describe an action that started in the past and is (or may be) still going on. This construction is called the present perfect. The past participle form of a regular verb is identical to the past form: it always ends in -ed: Olga has promised to help me.Max and Olga have finished the race.We have tried to do our best. The auxiliary verbhas or havechanges to agree with its subject (see Correcting Errors in Subject-Verb Agreement), but the past participle itself does not change: Carla has worked here for five years.Carla and Fred have worked here for five years. Use the past tense to show a completed action. Use the present perfect (has or have plus the past participle) to show an action begun in the past but continuing up to the present. Exercise: Forming the Past Tense and the Present-Perfect Complete the second sentence in each set with the correct form of the verb in parentheses. Use either the past tense or the present perfect tense (has or have plus the past participle). The first sentence in each pair will help you decide which tense is needed in the second sentence. Mr. Baggins lives in the house next door. He (live) there for the past eight years.We are still raising money for the scholarship drive. So far we (raise) over $2,000.I have gained five pounds since I started my diet. At the same time, I (gain) a craving for Milky Way bars.I watched the Jon Stewart show last night. Then I (watch) David Lettermans program.I have called you several times this week. You (call) me once last spring.Jenny frequently uses the new word processor. Kyle not (use*) it once.Several years ago I stayed two weeks on a farm. I (stay) in the city ever since.Addie shouted in my ear. I turned and (shout) right back.Lu ordered one book from the club last year. He not (order*) anything since.I have never tried to raise chickens. Once I (try) to raise hogs. * The negatives not and never often go between the auxiliary verb and the past participle in the present-perfect tense. Answers has livedhave raisedhave gainedwatchedcalledhas not usedhave stayedshoutedhas not orderedtried

Recommendations for a client business Essay Example | Topics and Well Written Essays - 750 words

Recommendations for a client business - Essay Example On the other hand, Strait’s business rival M.Y. China had their hostess at the podium to warmly greet the incoming guests and seat them most of the times. The restaurant manager also helped her seat the guests especially when more than one guest came in at the same time. This resulted in fewer complaints from customers and more importantly shorter periods in seating the customers. The hostess at M.Y. China is always in a jovial mood and welcomes guests in a friendly and a professional manner. It is apparent that from the customer comments that even when customers did not get her at the podium she made up with the welcoming gestures. She always engaged eye contact with her the guests, smiled and used a friendly tone when talking to them (Yelp). Therefore, Straits should put efforts in improving its service standards if it is to maintain its clientele, especially with increased competition from its next-door competitor M.Y. China. For instance, many customers have expressed diss atisfaction with declining food quality, service level and the restaurant’s general experience. The customers also bemoan the inattentiveness and the unprofessional manner with which the hostess and other workers behave themselves. Such negative perceptions from the customers may eventually hurt the restaurant’s business if they are not addressed. Some customers have complained about the absence of a clear job structure that results in ambiguity in the roles that different persons perform. For example, some guests have to wait to be ushered into the restaurant when the hostess is helping the servicer to clear the tables. Some customers also observed that the restaurant seems not to have an outlined task plan to ensure smooth flow of operations. This is apparent when customers who have made a reservation come into the restaurant and the hostess looks clueless when they enquire about their table. Sometimes she ends up mumbling some apologies and seating the guests in a d ifferent table. Recommendations The observers made some recommendations after a thorough evaluation of the service standards of Straits restaurant and comparing it to that of its competitor M.Y. China. Since the main issue was found to be the absence of the hostess at the podium, the group of observers formulated some recommendations that outlined tasks that would ensure that a hostess was always manning the podium area in order to greet and usher in incoming guests. The recommendations are outlined as follows: i. Organizing the reservations This would involve the hostess staying at the podium and organize any reservations that are made on the phone. The hostess should answer incoming machine messages to confirm that that all reservations have been noted. In addition, the hostess should schedule the reservations for all guests in advance and formulate a plan on how to receive and seat the guests as and when they arrive. This should include a seating chart. It is important for the ho stess to ask the guests some specific questions when they call in to make the reservations in order to have some basic information beforehand. Such information will assist the hostess in creating customer profiles that include names and contacts such as telephone numbers and e-mail addresses. However, the hostess may encounter problems that may be difficult to solve. For instance, what does the